mPEG DBCO, DBCO PEG Cat. No. PG1-DB-550 550 Da 20 mg修饰性聚乙二醇

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mPEG DBCO, DBCO PEG

Cat. No. PG1-DB-550
Specification 550 Da
Unit Size 20 mg
Price $385.00


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Synonym: DBCO PEG, mPEG DBCO, Methoxy PEG DBCO, Polyethylene glycol DBCO, mPEG550 DBCO

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Form: Semi-solid
  • Color: Yellow to light yellow
  • Solubility: Soluble in water
  • Reactive group: DBCO (Dibenzooctyne)
  • Reactive to: Azide group (-N3)
  • Purity: >95%

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.

References:

Click here to see hundred of publications using Nanocs PEGs.

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