Why PEGylation

Pegylation refers to a process of covalent attachment of PEG polymer chains to target molecules, normally small molecule chemical drugs or large bio-molecules like peptides, proteins, carbohydrates, lipids, oligonucleotides, antibody fragments, affinity ligands, cofactors, liposomes, and other bio-related substances.


Pegylation can impart several significant pharmacological advantages over the unmodified counterparts in the following attributes, improving drug performance and its therapeutic effect significantly:
– Extended circulating life;
– Lower maximum plasma concentration;
– Smaller fluctuation of concentration in blood;
– Less enzymatic degradation.


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