Storage and Handling Conditions for PEG and PEG reagents

All PEG and PEG reagents should be stored under an inert atmosphere, in the dark, at or below -15°C.

Derivatives such as the succinimidyl active esters (e.g., mPEG-SMB and mPEG2-NHS) and maleimides react with moisture. It is therefore essential to minimize exposure to moisture and to keep these materials cold to reduce their rate of hydrolysis. PEG aldehydes (e.g. mPEG-ButyrALD) can be oxidized by atmospheric oxygen to produce the
corresponding carboxylic acids, and mPEG-thiols can react with oxygen to produce disulfides. In addition, all PEGs react slowly with oxygen to form peroxides along the backbone in a process that is facilitated by light and heavy metal ions. These peroxides can lead to chain cleavage and increased polydispersity.

Shipment of PEG and PEG reagents at room temperature with no loss of activity and degradation of the backbone is possible following thorough drying and storage under an inert gas. Before dispensing PEG and PEG reagent(s) after storage, allow the reagent to warm to room temperature. After dispensing, the reagent container should be backfilled with an inert dry gas (e.g., argon or nitrogen) and stored again at or below -15°C. For multiple uses, consideration should be placed on dispensing the reagent upon receipt into several pre-weighed containers to reduce any risk of degradation due to cycling through multiple freeze-thaw cycles.

Utopbio offers custom packaging upon request at an additional charge.

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