Heterobifunctional PEGs

Heterobifunctional derivatives of PEG have the general structure X-PEG-Y and are extremely useful as macromolecular cross-linking agents or as spacers between two different entities.

In addition to the two independent functional groups, the presence of PEG provides water solubility, biocompatibility, flexibility, and a great degree of freedom for each of the linked components of X and Y. Applications reported in the literature include synthesis of enzymatically active cofactor-apoenzyme conjugates, preparation of graft polymeric supports for solid-phase peptide synthesis, targetable polymeric drugs, and PEG-grafts onto surfaces and proteins. These reagents are chromatographically purified to supply substitution values of the NH2-PEGCOOH at 95% or greater at each end group.

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