DODAP (1,2-dioleoyl-3-dimethylammonium-propane) Cat. No. DODAP-1 10 mg修饰性聚乙二醇

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DODAP (1,2-dioleoyl-3-dimethylammonium-propane)

Cat. No. DODAP-1
Specification
Unit Size 10 mg
Price $125.00


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Description:

DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with low cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases.

Specifications:

  • Form: Liquid;
  • Color: Light yellow liquid;
  • Formular: C41H77NO4;
  • Molecular weight: 648.05;
  • Lipid type: C18, un-saturated ionizable lipids;

Applications:

  • DNA, SiRNA, mRNA transfection;
  • Drug delivery;
  • Gene therapy;

Storage:

  • Store at -20 0C. Protect from light.
Additional Images
DODAP (1,2-dioleoyl-3-dimethylammonium-propane)           Cat. No. DODAP-1        10 mg
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