1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) and PDP conjugated Polyethylene Glycol is a heterobifunctional PEG derivative that can undergo reaction with sulfhydryl group. DSPE PEG is an 18 carbon phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. PDP (pyridyldithiol propionate) is reactive toward free thiol group to form cleavable disulfide bond. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in warm aqeous solution as well as most organic solvents;
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
|PG2-DSML-20k , DSPE PEG Maleimide, DSPE-PEG-MAL|
|PG2-AMDS-5k , DSPE PEG Amine, DSPE-PEG-NH2|