N-ethylmaleimide, NEM Cat. No. M-C2-2 CAS# 128-53-0 5 g修饰性聚乙二醇

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N-ethylmaleimide, NEM

Cat. No. M-C2-2
Specification CAS# 128-53-0
Unit Size 5 g
Price $685.00

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Description:

N-ethylmaleimide (NEM) is a water soluble, thiol reactive maleimide that can be used to modify protein cysteineresidues. Maleimide reacts with sulfhydryl groups at pH 6.5~7.5 to form stable thioether bonds. NEM has been used for protein Acyl-RAC assayN-ethylmaleimide is a sulfhydryl alkylating reagent that inhibits H+-ATPase and suppresses the short circuit current (IC50 = 22 µM) in pancreatic duct cells. N-ethylmaleimide Inactivates NADP-dependent isocitrate dehydrogenase. Also a potent inhibitor of both Mg2+ and Ca2+/Mg2+-stimulated DNA fragmentation in rat liver nuclei. NEM stimulates arachidonic acid release through activation of PLA2 in endothelial cells. As a commonly used sulfhydryl alkylating reagent, NEM has been used for blocking sulfhydryl containing reagents which interfere with glucose oxidase assays. Inactivates NADP-dependent isocitrate dehydrogenase. Endonuclease inhibitor. Also a potent inhibitor of both Mg2+ and Ca2+/Mg2+-stimulated DNA fragmentation in rat liver nuclei.

Physical Properties:

  • Appearance: Off-white/faint yellow solid
  • Mol Wt: 125.13
  • CAS No: 128-53-0
  • Purity: >98%

Storage Conditions:

  • Store at -20 0C. 
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