LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate)) Cat. No. SMCC-LC-1 MW 444.78 100 mg修饰性聚乙二醇


LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate))

Cat. No. SMCC-LC-1
Specification MW 444.78
Unit Size 100 mg
Price $485.00

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Name: LC-SMCC, Long chain-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

Synonym: LC-SMCC, long chain 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester


LC-SMCC, also called Long chain succinimidyl cyclohexane Maleimide, is one of  Nanocs' amine and sulfhydryl reactive crosslinkers. This crossliner is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group. Compared to other maleimide NHS ester, LC-SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties of SMCC:

  • Appearance: Off-white/white solid;
  • Molecular formula: C22H29N3O7;
  • Molecular weight: 447.48;
  • Reactive to: Sulfhydryl and primary amine group;
  • Purity: >95%
  • Soluble in DMF or DMSO;

Storage Conditions of LC-SMCC:

  • LC-SMCC should be stored at -20 0C or lower. Desiccate. Avoid frequent thaw and freeze.