4-Cyano-N,N,N-trimethylbenzenaminium triflate (PTAB)

Product Description:

4-Cyano-N,N,N-trimethylbenzenaminium triflate (PTAB) is a precusor to synthesize a number of benzyl-guanidine radio imaging agents for PET, SPECT to image norepinephrine transportor (NET). PTAB has been used successfully to synthesize [¹⁸F]PFBG (Para-[¹⁸F]fluorobenzylguanidine), an excellent PET imaging agent to detect hNET expression in-vivo (1, 2).  

Product Specifications:

• Appearance (form):    Solid;
• Appearance (color):   White:
• Molecular weight:       310.29 g/mol
• Purity:                         >98% (HPLC)

Storage Conditions:

PTAB should be stored at -20 ⁰C. Desiccate.

References:

1. Zhang, HW, et al Eur J Nucl Med Mol Imaging (2014) 41:322-332
2. Zhang, HW, et al Clin Cancer Res 2014 20(8) 2182-2191

4-Formy-N,N,N-trimethylbenzenaminium (PTAA)

Gold Nanoshells on Silica beads

Description:

Nanocs now provides gold nanoshell particles which are made from the growth of thin layer (2~5 nm) of gold on silica particles. These gold nanoshells provide multiple applications in biomolecule labeling, purification and analysis.

Nanocs also provides various surface modified gold nanoshell particles with a wide range of specifications to suit different applications.

Product Specifications:

• Composition: Gold nanoshell grown on silica beads;
• Gold layer thickness: 2 ~5 nm;
• Particle size: 100 nm to 50 microns;
• Color: Pale red to blue.

Storage Conditions:

• Store at 4 ⁰C.

Gold Nanoshells, amine functional

Description:

Nanocs now provides gold nanoshell particles which are made from the growth of thin layer (2~5 nm) of gold on silica particles. These gold nanoshells provide multiple applications in biomolecule labeling, purification and analysis.

Nanocs also provides various surface modified gold nanoshell particles with a wide range of specifications to suit different applications.

Product Specifications:

• Composition: Gold nanoshell grown on silica beads;
• Gold layer thickness: 2 ~5 nm;
• Particle size: 100 nm to 50 microns;
• Color: Pale red to blue.

Storage Conditions:

• Store at 4 ⁰C.

Selenium Nanoparticles

Description:

Selenium nanoparticles offered from Nanocs were made by well-controlled chemical method. These particles are dispersed in aqueous solution and showed bright orange to red color. Compared to element selenium, nanostructured selenium particles showed lower toxicity to biological tissues. These selenium nanoparticles are good free radical scanvengers and exert strong cellular protection effect from oxidative stress. Besides plain selenium nanoparticle solution, Nanocs also offers surface functionalized Se particles for different applications.

Product Specifications:

• Composition: Selenium nanoparticles in aqueous solution;
• Particle size: 25 nm to 150 nm;
• Color: Orange to orange red;
• Concentration: 0.1 mg/mL based on element selenium;

Storage Conditions:

• Store at 4 ⁰C. DO NOT FREEZE.

Bovine IgG, Gold Conjugate

Goat IgG, Gold Conjugate

Goat IgG, Gold Conjugate

Goat IgG, Gold Conjugate

Rabbit IgG, Gold Conjugate

Human IgG, Cy3 labeled

Human IgG, Gold Conjugate

Low molecular weight hylauronic acid (LMWHA), Rhodamine B labeled

Description:

Nanocs provides a variety of chemically functionalized and bioconjugated low molecular weight hylauronic acid (LMWHA) with different functionality. LMWHA has better solubility and permeability. These functional Hylauronic acid products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Specifications:

• 20~40 functional groups on each hylauronic acid molecule.
• Hylauronci acid conjugates provided either in water solution and dried powder;

Storage Conditions:

• Store4 ⁰C, dessiccated Protect from light.

Chitosan, fluorescein labeled, 120 kDa

Description:

Nanocs provides a variety of chemically functionalized and bioconjugated chitosan polysaccharide with different functionality. These functional chitosan products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Specifications:

• 10~50 functional groups on each chitosan molecule.
• Chitosan conjugates provided either in water solution and dried powder;

Storage Conditions:

• Store4 ⁰C, dessiccated Protect from light.

Chitosan, biotin labeled, 180 kDa

Description:

Nanocs provides a variety of chemically functionalized and bioconjugated chitosan polysaccharide with different functionality. These functional chitosan products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Specifications:

• 10~50 functional groups on each chitosan molecule.
• Chitosan conjugates provided either in water solution and dried powder;

Storage Conditions:

• Store4 ⁰C, dessiccated Protect from light.

Protein A, SF488 labeled

Description:

SF488 labeled Protein A is one of the Nanocs’ premier fluorescent Protein A conjugates. Protein A is a 42 kDa surface protein originally found in the cell wall of Stapylococcus aureus. Protein A has strong binding affinity towards immunoglobulins and it has been used for antibody identification, purification and many other biochemical research uses. SF488 is a green fluorescent dye with high fluorescent intensity and good photo stability. SF488 labeled protein A conjugate has excitation/emission wavelength at 495 nm/515 nm. All our protein A conjugates were purified by size exclusion chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Specifications:

• 2~7 SF488 dyes on each protein A molecule.
• Protein A and it conjugates provided either in water solution or dried powder;

Storage Conditions:

• Store at 4 ⁰C. Protect from light.

Human serum albumin, Biotin labeled

Description:

Nanocs provides a variety of chemically functionalized and bioconjugated Human serum albumin (HSA) with different functionality. These functional HSA products were purified by size exclusion chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Specifications:

• 2~7 functional groups on each HSA molecule.
• HSA conjugates provided either in water solution or dried powder;

Storage Conditions:

• Store at 4 ⁰C. Protect from light.

Casein, Rhodamine labeled

Description:

Nanocs provides a variety of chemically functionalized and bioconjugated Casein protein with different functionality. These functional casein products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Specifications:

• 2~7 functional groups on each casein molecule.
• Casein conjugates provided either in water solution or dried powder;

Storage Conditions:

• Store at 4 ⁰C. Protect from light.

DNP Dextran conjugate

DNP-OVA, DNP Ovalbumin Conjugate:

DNP-OVA is one of Nanocs 2,4-dinitrophenyl albumin (Ovalbumin from Egg white) conjugate that can be used for immunoassay development. DNP is a frequently used heptan that has strong absorption around 360 nm. Nanocs provides a number of DNP conjugates that can be used for different applications. These DNP conjugates were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Specifications:

• Form: Powder
• Color: Yellow
• DNP ratio: >30 DNP per OVA
• Source: Synthetic
• Absorption: 360 nm

Storage Conditions:

• Store at<4 ⁰C. Protect from light.

Succinimidyl PEG NHS, mPEG-NHS(SC)

Description:

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH₂) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Physical Properties:

• Off-white/white solid or viscous liquid depends on molecule weight;
• Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

• Store at -20 ⁰C, desiccate. NHS PEG tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Generally, a 10 to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

• Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
• PEG NHS stock solution: 100 mg in 1 mL conjugation buffer.
• Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add NHS PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG NHS needed for optimal conjugation; Allow mixture agitates at room temperature for 30~60 min at room temperature or 2 hours at 4 ⁰C. Conjugates can be purified either by size exclusion chromatography or dialysis.