Vancomycin FITC conjugate

Synonym: Vancomycin fluorescein, FITC Vancomycin, Fluorescein labeled vancomycin.

Fluorescein Vancomycin (FITC-Vancomycin) is one of Nanocs fluorescent bioconjugates that can be used to detect gram positive bacteria.  Vancomycin is an antibiotic used to treat a number of bacterial infections. FITC vancomycin has excitation/emission wavelength at 495 nm/515 nm.  Fluorescein labeled vancomycin can bind to gram positive bacteria and be detected easily by common fluorescent instruments. 

Product Specifications:

• Form: In DMSO solution
• Color: Yellow or orange
• Ex/Em wavelength: 495 nm/515 nm
• Concentration: 5-10 mg/mL

Storage Conditions:

• Store at -20 ⁰C. Protect from light.

Bisphosphonate PEG FITC

Synonym: Diphosphonate PEG FITC, Fluorescein PEG Bisphosphonate.

Bisphosphonate PEG FITC is one of Nanocs fluorescent bone tissue targeting reagents that emit green fluorescence. 

Specifications:

• Form: Powder.
• Color: Yellow/orange.
• Ex/Em wavelength: 495 nm/515 nm.
• Target: Osteo tissue.

Storage Conditions:

• Store at <4 ⁰C. Protect from light.

NHS PEG2 Biotin, Biotin PEG2 NHS

Synonym: NHS PEG2 Biotin, Biotin PEG2 Succinimidyl ester, Biotin PEG2 NHS.

Description:

Biotin PEG2 NHS, also named NHS PEG2 Biotin, is one of Nanocs reactive PEG biotin reagents that have distinct PEG units. Biotin PEG2 NHS contains a 2 units ethylene glycol (-CH2CH2O-) between biotin and NHS (succinimidyl). NHS activated biotin can be used to label proteins, antibodies, small molecules or surfaces via their available amine groups. NHS reacts quickly with primary amine groups under alkaline pH to yield a stable amide bond. This reaction allows rapid attachement of biotin tag to targeted molecules or material surfaces. Resulted biotin tag can be easily detected with avidin or streptavidin. PEG linker between NHS and Biotin offers better water solubility, flexible linker structure and enhanced stability. 

Physical Properties:

• Form: Solid
• Color: White
• Solubility: Soluble in aqueous buffer
• Reactive group: NHS (succinimidyl ester)
• Reactive to: Primary amine group (-NH2)
• PEG unis: two
• Applications: Biotin conjugation (Biotinylation)
• Purity: >95%

Storage Conditions:

• Store at -20 ⁰C. Desiccate. Avoid frequent thaw and freeze.

References:

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Biotin PEG4 NHS, NHS PEG4 Biotin

Synonym: NHS PEG4 Biotin, Biotin PEG4 Succinimidyl ester, Biotin PEG4 NHS.

Description:

Biotin PEG4 NHS, also named NHS PEG4 Biotin, is one of Nanocs reactive PEG biotin reagents that have distinct PEG units. Biotin PEG4 NHS contains 4 ethylene glycol (-CH2CH2O-)  units between biotin and NHS (succinimidyl). NHS activated biotin can be used to label proteins, antibodies, small molecules or surfaces via their available amine groups. NHS reacts quickly with primary amine groups under alkaline pH to yield a stable amide bond. This reaction allows rapid attachement of biotin tag to targeted molecules or material surfaces. Resulted biotin tag can be easily detected with avidin or streptavidin. PEG linker between NHS and Biotin offers better water solubility, flexible linker structure and enhanced stability. 

Physical Properties:

• Form: Solid
• Color: White
• Solubility: Soluble in aqueous buffer
• Reactive group: NHS (succinimidyl ester)
• Reactive to: Primary amine group (-NH2)
• PEG unis: four
• Applications: Biotin conjugation (Biotinylation)
• Purity: >95%

Storage Conditions:

• Store at -20 ⁰C. Desiccate. Avoid frequent thaw and freeze.

References:

Click here to check hundreds publications using Nanocs PEGs.

Lipoic acid PEG Hydrazide

Synonym: Hydrazide PEG Lipoic acid,  Lipoic acid-PEG-CONHNH2, LPA-PEG-CONHNH2.

Description:

Lipoic acid PEG Hydrazide (Lipoic acid-PEG-CONHNH2) is one of Nanocs carbonyl reactive PEG derivatives that have a lipoic acid group on one end of PEG and a hydrazide group (-NHNH2) on the other terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Hydrazide group (-NHNH2), on the other hand, can react with aldehyde or ketone groups derived from polysaccarides or glycoproteins. Reaction between hydrazide and ketone group results in a stable hydrazone bond, which is more stable than the schiff base formed between amine and ketone group. 

Product Specification:

• Form: Solid powder or semi-solid depends on PEG length
• Color: Yellow to pale yellow
• Reactive group: Hydrazide (-CONHNH2)
• Reactive to: Aldehyde/ketone
• Solubility: Soluble in water

Storage Conditions:

• Store at -20 ⁰C. 

Lipoic acid PEG Alkyne

Synonym: Alkyne PEG Lipoic acid,  Lipoic acid-PEG-Alkyne, LPA-PEG-Alkyne.

Description:

Lipoic acid PEG Alkyne (LPA-PEG-Alkyne) is one of Nanocs click chemistry reactive PEG derivatives that have a lipoic acid group on one end of PEG and an alkynde on the other terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Alkyne, on the other hand, can react with azide group in aqueous solution via so called Click Chemistry.  Reaction between alkyne and azide results in a stable conjugation of Lipoic acid PEG to targeted substrates.

Product Specification:

• Form: Solid powder or semi-solid depends on PEG length
• Color: Yellow to pale yellow
• Reactive group: Alkyne
• Reactive to: Azide
• Solubility: Soluble in water

Storage Conditions:

• Store at -20 ⁰C. 

Lipoic acid PEG DBCO

Synonym: DBCO PEG Lipoic acid, LPA-PEG-DBCO.

Description:

Lipoic acid PEG DBCO is one of Nanocs Click Chemistry reactive PEG derivatives that have a lipoic acid group on one end of PEG chain and a DBCO group (Dibenzocyclooctyne) on the other PEG terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. DBCO, on the other hand, is able to react with azide group via so called copper-free click chemistry reaction. Reaction between DBCO and azide allows efficient conjugation of Lipoic acid to targeted molecules quickly and easily. 

Product Specification:

• Form: Solid powder or semi-solid depends on PEG length
• Color: Yellow to pale yellow
• Reactive group: DBCO
• Reactive to: Azide/Azido
• Solubility: Soluble in water

Storage Conditions:

• Store at -20 ⁰C. 

Lipoic acid PEG Cy5

Synonym: Thioctic acid PEG Cy5, Cy5 PEG Lipoic acid, LPA-PEG-Cy5.

Similar products: Lipoic acid PEG SF650, Alexa Fluor 647 PEG Lipoic acid

Description:

Lipoic acid PEG Cy5 is one of Nanocs fluorescent PEG derivatives that have a lipoic acid group on one end of PEG chain and a Cy5 fluorescent dye on the other PEG terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Cy5, on the other hand, is a bright cyanine dye that has excitation/emission wavelength at 650 nm/670 nm. Cy5 labeled lipoic acid PEG can be easily detected with common fluorescent instruments.

Product Specification:

• Form: Solid powder or semi-solid depends on PEG length
• Color: Blue or dark blue
• Fluorescent dye: Cy5
• Ex/Em: 650 nm/670 nm
• Solubility: Soluble in water

Storage Conditions:

• Store at -20 ⁰C. Protect from light.

Cy3 PEG Lipoic acid

Synonym: Thioctic acid PEG Cy3, Cy3 PEG Lipoic acid, LPA-PEG-Cy3.

Similar products: Lipoic acid PEG SF550, Alexa Fluor 546 PEG Lipoic acid

Description:

Lipoic acid PEG Cy3 is one of Nanocs fluorescent PEG derivatives that have a lipoic acid group on one end of PEG chain and a Cy3 fluorescent dye on the other PEG terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Cy3, on the other hand, is a bright cyanine dye that has excitation/emission wavelength at 550 nm/570 nm. Cy3 labeled lipoic acid PEG can be easily detected with common fluorescent instruments.

Product Specification:

• Form: Solid powder or semi-solid depends on PEG length
• Color: Pink
• Fluorescent dye: Cy3
• Ex/Em: 550 nm/570 nm
• Solubility: Soluble in water

Storage Conditions:

• Store at -20 ⁰C. Protect from light.

Doxorubicin PEG DSPE

Similar Names: Adriacin PEG DSPE, Adriamycin PEG DSPE, Dox PEG  DSPE, 14-hydroxydaunomycin PEG DSPE

Doxorubicin PEG DSPE is one of Nanocs' bioactive phospholipid conjugates that can be used to make bioactive liposomes. Doxorubicin is a water soluble anthracyclin antibiotic used in the treatment of a wide range of cancers. Doxorubicin inhibits DNA and RNA but not protein synthesis in intact cells. DSPE  PEG conjugated Doxorubicin can be used to make pegylated liposome that prolongs the circulation time of doxorubicin in blood.

Product Specifications:

• Form: Powder
• Color: Red
• Solubility: Soluble in chloroform
• Type: bioactive phospholipid

Storage:

• Store at -20 ⁰C. Protect from light.

DMPE PEG, mPEG-DMPE

Description:

1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine (DMPE) conjugated Polyethylene Glycol, DMPE PEG is a phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

• Off-white/white solid or viscous liquid depends on molecule weight;
• Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

• Store at -20 ⁰C. Avoid frequent thaw and freeze.

mPEG-DBCO, DBCO PEG

Synonym: DBCO PEG, mPEG DBCO, Methoxy PEG DBCO, Polyethylene glycol DBCO, mPEG350 DBCO

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

• Form: Liquid
• Color: Yellow to light yellow
• Solubility: Soluble in water
• Reactive group: DBCO (Dibenzooctyne)
• Reactive to: Azide group (-N3)
• Purity: >95%

Copper-free Click reaction procedures:

• Prepare the azide-containing reagents in reaction buffer.
• Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
• Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 ⁰C.
• Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

• Store at -20 ⁰C; Desiccate; Avoid frequent thaw and freeze.

References:

Click here to see hundred of publications using Nanocs PEGs.

mPEG DBCO, DBCO PEG

Synonym: DBCO PEG, mPEG DBCO, Methoxy PEG DBCO, Polyethylene glycol DBCO, mPEG550 DBCO

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

• Form: Semi-solid
• Color: Yellow to light yellow
• Solubility: Soluble in water
• Reactive group: DBCO (Dibenzooctyne)
• Reactive to: Azide group (-N3)
• Purity: >95%

Copper-free Click reaction procedures:

• Prepare the azide-containing reagents in reaction buffer.
• Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
• Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 ⁰C.
• Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

• Store at -20 ⁰C; Desiccate; Avoid frequent thaw and freeze.

References:

Click here to see hundred of publications using Nanocs PEGs.

4 arm Norbornene PEG

Synonym: 4 arm PEG norbornene, 4 arm Norbornene PEG, 4 branched Norbornene PEG

Description:

4 Arm norbornene PEG is one of Nanocs thiol-ene Click Chemistry reactive PEG derivatives that can be used for hydrogel synthesis, nanoparticle modification and new polymer synthesis. Norbornene is an excellent dienophile that can react with thiol group through thiol-ene Michael addition Click Chemistry reaction. It is also an ideal dienophile that can react rapidly and specifically with tetrazine through strain-promoted cycloaddition (1,2). Nanocs provides a number of norbornene functional PEGs that can react with various functional groups. Resulted norbornene group can be used to react with thiol or tetrazine rapidly  in aqueous solution.

Product Specification:

• Form: Solid powder
• Color: White
• Solubility: Soluble in water
• Reactive to: Thiol (-SH)
• Purity: >95%

Storage:

• Store at -20 ⁰C.

References:

1. Neal K.Devaraj, et al Bioconjug Chem. 2008, 19(12):2297-2299
2. M.  K. Narayanam, et al Chem Sci, 2016, 7, 1257-1261

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Norbornene PEG NHS

Synonym: NHS PEG Norbornene, Norbornene PEG5000 NHS, NHS PEG5000 Norbornene

Description:

Norbornene PEG NHS is one of Nanocs Click Chemistry PEG Reagents that have a Norbornene group on one end of PEG chain and a succinimidyl NHS group on the other PEG terminus. Norbornene is a strain-promoted dienophile that has been used in thiol-ene click chemistry to react with thiols. It also an excellent Click Chemistry reagent used in tetrazine-norbornene cycloaddition.  Meanwhile, NHS group  allows conjugation of Norbornene group to various molecules via their amine groups. Resulted Norbornene group thus can participate various Click Chemistry reactions.  PEG linker between Norbornene and NHS offers good water solubility, better stability or flexible linker structure.

Product Specifications:

• Form: Solid powder
• Color: White
• Solubility: Soluble in water
• Reactive groups: Norbornene, NHS
• Reactive to: Thiol, tetrazine, amine
• Purity: >95%
• Applications: Thiol-ene and tetrazine-norbornene  click chemistry

Storage:

• Store at -20 ⁰C. Desiccate.

Norbornene PEG Biotin

Synonym: Biotin PEG Norbornene, Norbornene PEG5000 Biotin, Biotin PEG5000 Norbornene

Description:

Norbornene PEG Biotin is one of Nanocs Click Chemistry PEG Reagents that have a Norbornene group on one end of PEG chain and a biotin tag on the other PEG terminus. Norbornene is a strain-promoted dienophile that has been used in thiol-ene click chemistry to react with thiols. It also an excellent Click Chemistry reagent used in tetrazine-norbornene cycloaddition.  Meanwhile, biotin tag  can bind to avidin or streptavidin with high affinity. Biotin PEG Norbornene can participate various Click Chemistry reactions.  PEG linker between Norbornene and Biotin offers good water solubility, better stability or flexible linker structure.

Product Specifications:

• Form: Solid powder
• Color: White
• Solubility: Soluble in water
• Reactive groups: Norbornene, Biotin
• Reactive to: Thiol, tetrazine, amine
• Purity: >95%
• Applications: Thiol-ene and tetrazine-norbornene  click chemistry

Storage:

• Store at -20 ⁰C. Desiccate.